BioPure Zeolite Binder

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Histamine Intolerance

The human body is designed to process or deactivate histamines via diamine oxidase enzymes (DAO) found in the gastrointestinal tract. DAO enzymes chemically alter histamines or deactivate them so they cannot be reabsorbed and circulate throughout the body. However, that process has its limitations.

The body cannot keep up with demand when too little DAO is made or too many histamines are circulating. However, zeolite jumps over that limitation. It simply binds up histamine in the gastrointestinal tract, hides histamine away from the body in its porous cavities, and directly eliminates it via the stool. It bypasses histamine regulatory systems (such as DAO, HNMT, and MAO).

As it works in the gastrointestinal tract, it does not work on histamine generated elsewhere in the body, only that found in the gut.

Here are a few ways zeolite has been found to help histamine degradation.


Digested histamines are firmly bound to zeolite when consumed within 30 minutes of food. Indeed, studies show that up to 82% of ingested histamines are bound. 

Diamine Oxidase Deficiency

A small animal study found zeolite was protective of diamine oxidase levels and intestinal barrier function. 

Histamine Producing Gut Bacteria

In addition to binding to the histamine released by pathogenic gut bacteria, zeolite has also been found to bind to some pathogenic bacteria. This includes Escherichia coli, Staphylococcus aureus, Salmonella, Streptococcus mutans, Streptococcus mitis, and Pseudomonas aeruginosa.

Helicobacter (H. Pylori), a common gut infection, is also been inhibited. By binding to excess ammonia in the gut, zeolite creates an environment where H. Pylori cannot thrive. 

Leaky Gut

A substantial human study of zeolite supplementation found a 30% improvement in zonulin (a marker of intestinal integrity) with no change in the status of critical nutrients. A 2017 animal study also found that zeolite significantly improved gut villus (height, perimeter, section area) in the gut mucosa.  It appears that zeolite reinforces or coats the mucosal barrier such that it improves intestinal wall integrity. 

Inflammatory Bowel Disease

Inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease 2018 animal study found that zeolite reduced gut inflammation and that an inflamed gut can be exposed to zeolite for a prolonged time. 

Mast Cell Activation

The outer cell wall of gram-negative bacteria contains pro-inflammatory lipopolysaccharides, which activate mast cells. In an animal study, zeolite acted as an anti-inflammatory, preventing lipopolysaccharides from stimulating a variety of inflammatory markers and also regulating the immune system.

Other Health Benefits of Zeolite

Zeolite, more specifically clinoptilolite, is an intelligent binder. It only attaches to harmful substances and does not alter trace elements, minerals, or vitamins, even for long-term use.

Other than excess histamine, clinoptilolite has been shown to bind the following toxins: Heavy metals,Viruses, Mold toxins,Radioactive materials, and Flouride. 

Assisting the body to detoxify, supporting an inflamed liver, and sparing the kidneys.

Other health benefits of  include the restoration of the body’s reserves of antioxidants, minerals, and the microbiome, which would otherwise be used for detoxification.

BioPure Zeolite Bind Supplement Powder

BioPure ZeoBind® is a potent combination of clinoptilolite and mordenite. Supports heavy metal removal via the gastrointestinal system.*