A recently published randomized and controlled double blind clinical trial concluded that when participants with obesity were supplemented withSaccharomyces boulardiiand superoxide dismutase, they had a number of improvements related to body composition and insulin sensitivity compared to the group receiving placebo. In a total of 25 study participants, both groups were also asked to moderately reduce their caloric intake, though only those receiving the active treatment had a significant reduction in weight (−2.73 kg total weight, and −0.97 kg/m2 in BMI). The active group also had a significant decrease in fat mass as measured by DEXA, without any change in fat-free mass, as well as significant reductions in fasting insulin, HOMA index, and uric acid. The group receiving the active treatment also had a significant increase in 25-OH vitamin D levels.
Although a small study, it may be the first human clinical trial ofS. boulardiiand SOD as a means of improving metabolic health and reducing adiposity in individuals with obesity. Animal studies have indicated thatS. boulardii’s probiotic effect is likely responsible for improvements in insulin sensitivity and reduced fat mass, while SOD has shown similar benefits in animal modelsthrough an antioxidant/anti-inflammatory mechanism.
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